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          Claudin-2 (8H11) Mouse mAb

          Catalog No. : EM1403

          规格 价格
          50µl ¥1280
          100µl ¥1980


          Product name: Claudin-2 (8H11) Mouse mAb
          Source: Mouse
          Applications: WB, IHC
          Species reactivity: Human,Rat,Mouse
          Recommended dilutions: WB 1:1,000-2,000   IHC:1;100-1:200
          Immunogen: Synthetic Peptide
          Specificity: Human
          Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
          Clonality: Monoclonal
          Isotype: IgG1
          Concentration: 1mg/ml
          Observed band: 25kDa
          GeneID(Human): 9075
          Human Swiss-Prot No.: P57739
          Cellular localization: Cell junction,tight junction,Cell membrane
          Alternative Names: N/A
          Background: The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .
          • Western blot analysis of 1) Hela Cell Lysate, 2) Mouse Heart Tissue Lysate , 3) Rat Heart Tissue Lysate using Claudin-2 (EM1403)Mouse mAb diluted at 1:2000.

          • Immunohistochemical analysis of paraffin-embedded Human Kidney Carcinoma Tissue using Claudin-2 (EM1403)Mouse mAb diluted at 1:200.

          • Immunohistochemical analysis of paraffin-embedded Human Endometrial Carcinoma Tissue using Claudin-2 (EM1403)Mouse mAb diluted at 1:200.