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          ASC Polyclonal Antibody
          

				
          Catalog No. :  ES1715
          

				

				
          

				

			
          



			
          

				
          

					

						
          

							规格

							价格

						
          

					          

					

						
						
          

							50µl

							￥1280

						
          

						
						
						
          

							100µl

							￥1980

						
          

						
						
					          

				
          

			
          

		
          

		

		
          

			
          Overview
          

			
			
			
			
			
			
			
			
			
				
				
          

          Product name：
ASC Polyclonal Antibody

          

          Alternative Names：
PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylatio

          

          Applications：
WB,IHC-p,IF,ELISA

          

          Reactivity：
Human,Mouse,Rat

          

          Gene Name：
PYCARD

          

          Protein Name：
Apoptosis-associated speck-like protein containing a CARD

          

          Human Gene Id：
29108

          

          Human Swiss Prot No：
Q9ULZ3

          

          Mouse Gene Id：
66824

          

          Mouse Swiss Prot No：
Q9EPB4

          

          Immunogen：
The antiserum was produced against synthesized peptide derived from human ASC. AA range:10-59

          

          Specificity：
ASC Polyclonal Antibody detects endogenous levels of ASC protein.

          

          Formulation：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

          

          Source：
Rabbit

          

          Dilution：
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

          

          Purification：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

          

          Concentration：
1 mg/ml

          

          Storage Stability：
-20°C/1 year

          

          MolecularWeight(Da)：
21627

          

          Observed Band(KD)：
21

          

          Background：
PYD and CARD domain containing(PYCARD)  Homo sapiens    This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

          

          Function：
domain:Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.,function:Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase 9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.,miscellaneous:In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death.,PTM:Phosphorylated.,similarity:Contains 1 CARD domain.,similarity:Contains 1 DAPIN domain.,subcellular location:Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.,subunit:Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PY

          

          Subcellular Location：
extracellular region,nucleus,nucleolus,cytoplasm,mitochondrion,endoplasmic reticulum,cytosol,IkappaB kinase complex,neuronal cell body,NLRP1 inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex,

          

          Expression：
 Colon mucosa,Fibroblast,Leukemia,Lymph,Pancreas,

          

          


          

            
					
          

          
			
		
          

		
		
          

			
            

				
				
				
				
				
				
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