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        Lamin B1 Polyclonal Antibody

        Catalog No. : ES2697

        规格 价格
        50µl ¥1280
        100µl ¥1980

        Overview

        Product name: Lamin B1 Polyclonal Antibody
        Alternative Names: LMNB1; LMN2; LMNB; Lamin-B1
        Applications: IF,WB,IHC-p,ELISA
        Reactivity: Human,Mouse,Rat
        Gene Name: LMNB1
        Protein Name: Lamin-B1
        Human Gene Id: 4001
        Human Swiss Prot No: P20700
        Mouse Gene Id: 16906
        Mouse Swiss Prot No: P14733
        Rat Gene Id: 116685
        Rat Swiss Prot No: P70615
        Immunogen: The antiserum was produced against synthesized peptide derived from human Lamin B1. AA range:26-75
        Specificity: Lamin B1 Polyclonal Antibody detects endogenous levels of Lamin B1 protein.
        Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
        Source: Rabbit
        Dilution: IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
        Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
        Concentration: 1 mg/ml
        Storage Stability: -20°C/1 year
        MolecularWeight(Da): 66408
        Observed Band(KD): 67
        Background: lamin B1(LMNB1) Homo sapiens This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
        Function: disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle
        Subcellular Location: nuclear envelope,nuclear inner membrane,lamin filament,nucleoplasm,membrane,nuclear matrix,nuclear membrane,
        Expression: Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,