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        Lamin B1 Polyclonal Antibody
        
				
        Catalog No. :  ES2697
        
				
				
        
				
			
        

			
        
				
        
					
						
        
							规格
							价格
						
        
					        
					
												
        
							50µl
							￥1280
						
        
																		
        
							100µl
							￥1980
						
        
																	        
				
        
			
        
		
        
		
		
        
			
        Overview
        
																																
        

        Product name：
Lamin B1 Polyclonal Antibody

        

        Alternative Names：
LMNB1; LMN2; LMNB; Lamin-B1

        

        Applications：
IF,WB,IHC-p,ELISA

        

        Reactivity：
Human,Mouse,Rat

        

        Gene Name：
LMNB1

        

        Protein Name：
Lamin-B1

        

        Human Gene Id：
4001

        

        Human Swiss Prot No：
P20700

        

        Mouse Gene Id：
16906

        

        Mouse Swiss Prot No：
P14733

        

        Rat Gene Id：
116685

        

        Rat Swiss Prot No：
P70615

        

        Immunogen：
The antiserum was produced against synthesized peptide derived from human Lamin B1. AA range:26-75

        

        Specificity：
Lamin B1 Polyclonal Antibody detects endogenous levels of Lamin B1 protein.

        

        Formulation：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

        

        Source：
Rabbit

        

        Dilution：
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

        

        Purification：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

        

        Concentration：
1 mg/ml

        

        Storage Stability：
-20°C/1 year

        

        MolecularWeight(Da)：
66408

        

        Observed Band(KD)：
67

        

        Background：
lamin B1(LMNB1) Homo sapiens    This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

        

        Function：
disease:Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.,function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle

        

        Subcellular Location：
nuclear envelope,nuclear inner membrane,lamin filament,nucleoplasm,membrane,nuclear matrix,nuclear membrane,

        

        Expression：
 Brain,Cajal-Retzius cell,Epithelium,Eye,Fetal brain cortex,Ovarian carcinoma,Placenta,Uterus,

        

        


        

          
					
        

        					
        
				
        
			
          
																								
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