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              PTEN Polyclonal Antibody

              Catalog No. : ES8470

              规格 价格
              50µl ¥1280
              100µl ¥1980


              Product name: PTEN Polyclonal Antibody
              Alternative Names: phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1
              Applications: IF,WB,IHC-p,ELISA
              Reactivity: Human,Mouse,Rat
              Gene Name: PTEN MMAC1 TEP1
              Protein Name: PTEN
              Human Gene Id: 5728
              Human Swiss Prot No: P60484
              Mouse Gene Id: 19211
              Mouse Swiss Prot No: O08586
              Immunogen: Synthesized peptide derived from PTEN at AA range: 251-300
              Specificity: PTEN Polyclonal Antibody detects endogenous levels of PTEN
              Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
              Source: Rabbit
              Dilution: IF: 1:50-200 IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000
              Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
              Concentration: 1 mg/ml
              Storage Stability: -20°C/1 year
              MolecularWeight(Da): 47166
              Observed Band(KD): 50
              Background: phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
              Function: catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,cofactor:Magnesium.,disease:A microdeletion of chromosome 10q23 involving PTEN and BMPR1A is a cause of chromosome 10q23 deletion syndrome [MIM:612242]. This syndrome shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome.,disease:Defects in PTEN are a cause of Bannayan-Zonana syndrome (BZS) [MIM:153480]; also known as Ruvalcaba-Riley-Smith or Bannayan-Riley-Ruvalcaba syndrome (BRRS). In BZS there seems not to be an increased risk of malignancy. It has a partial clinical overlap with CD. BZS is characterized by the classic triad of macroce
              Subcellular Location: extracellular region,nucleus,nucleoplasm,cytoplasm,mitochondrion,cytosol,plasma membrane,cytoplasmic side of plasma membrane,apical plasma membrane,PML body,myelin sheath adaxonal region,cell projection,neuron
              Expression: Epithelium,Lung,