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      Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody

      Catalog No. : ES1002

      规格 价格
      50µl ¥1280
      100µl ¥1980

      Overview

      Product name: Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody
      Alternative Names: CASP3; CPP32; Caspase-3; Caspase 3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
      Applications: WB,IF,IHC-p,ELISA
      Reactivity: Human,Mouse,Rat
      Gene Name: CASP3
      Protein Name: Caspase-3
      Human Gene Id: 836
      Human Swiss Prot No: P42574
      Mouse Gene Id: 12367
      Mouse Swiss Prot No: P70677
      Rat Gene Id: 25402
      Rat Swiss Prot No: P55213
      Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 3. AA range:126-175
      Specificity: Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
      Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      Source: Rabbit
      Dilution: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
      Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      Concentration: 1 mg/ml
      Storage Stability: -20°C/1 year
      MolecularWeight(Da): 31608
      Observed Band(KD): 20
      Background: caspase 3(CASP3) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],
      Function: catalytic activity:Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position.,enzyme regulation:Inhibited by isatin sulfonamides.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.,PTM:Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Ad
      Subcellular Location: nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,death-inducing signaling complex,membrane raft,
      Expression: Cervix,Lymph,T-cell,