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        Bax Polyclonal Antibody

        Catalog No. : ES6947

        规格 价格
        50µl ¥1280
        100µl ¥1980

        Overview

        Product name: Bax Polyclonal Antibody
        Applications: IHC-p,IF,WB,ELISA
        Reactivity: Human,Mouse,Rat
        Gene Name: BAX
        Protein Name: Apoptosis regulator BAX
        Human Gene Id: 581
        Human Swiss Prot No: Q07812
        Mouse Gene Id: 12028
        Immunogen: The antiserum was produced against synthesized peptide derived from human BAX. AA range:80-129
        Specificity: Bax Polyclonal Antibody detects endogenous levels of Bax protein.
        Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
        Source: Rabbit
        Dilution: WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
        Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
        Concentration: 1 mg/ml
        Storage Stability: -20°C/1 year
        MolecularWeight(Da): 21184
        Observed Band(KD): 22
        Background: The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
        Function: disease:Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma.,domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis.,similarity:Belongs to the Bcl-2 family.,subcellular location:Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, redistributes to the mitochondrion membrane through the release from JNK-phosphorylated 14-3-3 proteins.,subunit:Homodimer. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1