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              Bcl-2 Polyclonal Antibody

              Catalog No. : ES1759

              规格 价格
              50µl ¥1280
              100µl ¥1980

              Overview

              Product name: Bcl-2 Polyclonal Antibody
              Alternative Names: BCL2; Apoptosis regulator Bcl-2
              Applications: WB,IHC-p,IF,ELISA
              Reactivity: Human
              Gene Name: BCL2
              Protein Name: Apoptosis regulator Bcl-2
              Human Gene Id: 596
              Human Swiss Prot No: P10415
              Mouse Swiss Prot No: P10417
              Immunogen: The antiserum was produced against synthesized peptide derived from human BCL-2. AA range:26-75
              Specificity: Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2 protein.
              Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
              Source: Rabbit
              Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
              Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
              Concentration: 1 mg/ml
              Storage Stability: -20°C/1 year
              MolecularWeight(Da): 26266
              Observed Band(KD): 26
              Background: BCL2, apoptosis regulator(BCL2) Homo sapiens This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
              Function: disease:A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.,domain:The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.,function:Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activati
              Subcellular Location: nucleus,cytoplasm,mitochondrion,mitochondrial outer membrane,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,membrane,integral component of membrane,nuclear membrane,mitochondrial membrane,myelin sheath,p
              Expression: Testis,