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      Bcl-2 Polyclonal Antibody

      Catalog No. : ES8474

      规格 价格
      50µl ¥1280
      100µl ¥1980

      Overview

      Product name: Bcl-2 Polyclonal Antibody
      Alternative Names: B-cell CLL/lymphoma 2
      Applications: WB,IHC-p,ELISA
      Reactivity: Mouse,Rat
      Gene Name: BCL2
      Protein Name: Bcl-2
      Human Gene Id: 596
      Human Swiss Prot No: P10415
      Mouse Gene Id: 12043
      Mouse Swiss Prot No: P10417
      Rat Swiss Prot No: P49950
      Immunogen: Synthesized peptide derived from Bcl-2 . at AA range: 10-90
      Specificity: Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2
      Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      Source: Rabbit
      Dilution: WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
      Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      Concentration: 1 mg/ml
      Storage Stability: -20°C/1 year
      MolecularWeight(Da): 26266
      Observed Band(KD): 22
      Background: BCL2, apoptosis regulator(BCL2) Homo sapiens This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
      Function: disease:A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.,domain:The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.,function:Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activati
      Subcellular Location: nucleus,cytoplasm,mitochondrion,mitochondrial outer membrane,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,membrane,integral component of membrane,nuclear membrane,mitochondrial membrane,myelin sheath,p
      Expression: Testis,