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      当前位置：首页产品展示一抗多克隆抗体
      

      

      
	
      
		
		
      
			
      
				
      
				
      Bcl-2 Polyclonal Antibody
      
				
      Catalog No. :  ES8474
      
				
				
      
				
			
      

			
      
				
      
					
						
      
							规格
							价格
						
      
					      
					
												
      
							50µl
							￥1280
						
      
																		
      
							100µl
							￥1980
						
      
																	      
				
      
			
      
		
      
		
		
      
			
      Overview
      
																																
      

      Product name：
Bcl-2 Polyclonal Antibody

      

      Alternative Names：
B-cell CLL/lymphoma 2

      

      Applications：
WB,IHC-p,ELISA

      

      Reactivity：
Mouse,Rat

      

      Gene Name：
BCL2

      

      Protein Name：
Bcl-2

      

      Human Gene Id：
596

      

      Human Swiss Prot No：
P10415

      

      Mouse Gene Id：
12043

      

      Mouse Swiss Prot No：
P10417

      

      Rat Swiss Prot No：
P49950

      

      Immunogen：
Synthesized peptide derived from Bcl-2 . at AA range: 10-90

      

      Specificity：
Bcl-2 Polyclonal Antibody detects endogenous levels of Bcl-2

      

      Formulation：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

      

      Source：
Rabbit

      

      Dilution：
WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300

      

      Purification：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

      

      Concentration：
1 mg/ml

      

      Storage Stability：
-20°C/1 year

      

      MolecularWeight(Da)：
26266

      

      Observed Band(KD)：
22

      

      Background：
BCL2, apoptosis regulator(BCL2) Homo sapiens    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

      

      Function：
disease:A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.,domain:The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.,function:Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activati

      

      Subcellular Location：
nucleus,cytoplasm,mitochondrion,mitochondrial outer membrane,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,membrane,integral component of membrane,nuclear membrane,mitochondrial membrane,myelin sheath,p

      

      Expression：
 Testis,

      

      


      

        
					
      

      					
      
				
      
			
        
																								
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